ESPE Abstracts

Background: We previously reported that children with an earlier adiposity rebound (AR), which is defined as the time at which the BMI starts to rise after infancy, have a higher BMI and a greater atherogenic metabolic status at age 12. In addition, it has been reported that higher levels of leptin at age 3 is associated with greater weight gain and adiposity by age 7. This finding suggests that leptin resistance may begin in early childhood, even before age 3.<p class="ab...

Background: Childhood obesity starts in early childhood. The natural history of childhood obesity has not been reported and it is unknown how obese children in early childhood improve to become non-obese adolescents.Objective and hypotheses: To investigate the natural history of obese children from early childhood to puberty and identify patterns and trends in this process.Method: 1207 children (614 boys and 593 girls) born in Fuji...

Background: Microdeletion of 14q22q23 results in a rare chromosomal disorder associated with microphthalmia/anophthalmia, pituitary anomalies, polydactyly/syndactyly, micrognathia, growth restriction and mental retardation. Haploinsufficiency of the genes OTX2 (orthodenticle homeobox 2) and BMP4 (bone morphogenetic protein 4) are responsible for most of the phenotypic features in the 14q22q23 microdeletion syndrome. There are only a few reports about liver dys...

Back ground: The incidence rate of vitamin D deficiency is increasing throughout the world in recent years, but the rate of vitamin D deficiency in Japan is unknown.Aims: We measured the incidence rate of vitamin D deficiency in 12-year old children in Japan.Methods: A total of 492 children (247 boys and 245 girls) from one Japanese community enrolled in this study. At age 12, 25 hydroxyvitamin D (25OHD) were measured in all childr...

Background: Aldosterone synthase deficiency (ASD) is a rare autosomal recessive disease, presenting with salt wasting and failure to thrive in early infancy. It is caused by inactivating mutations of the CYP11B2 gene.Objective and hypotheses: Our objective was to describe a Japanese patient with ASD, who presented with failure to thrive and salt wasting.Method: We present a case report and investigate molecular analysis of CYP11B2 ...